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Ezetimibe;(3-R,4-S)-1-(4-fluoromethyl)-3[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetridin-2-one

Compound with spectra: 5 NMR, 1 FTIR, and 11 MS (LC)

Ezetimibe;(3-R,4-S)-1-(4-fluoromethyl)-3[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetridin-2-one
SpectraBase Compound ID CIQZFJGp47i
InChI InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1
InChIKey OLNTVTPDXPETLC-XPWALMASSA-N
Mol Weight 409.43 g/mol
Molecular Formula C24H21F2NO3
Exact Mass 409.14895 g/mol
Enantiomer InChIKey OLNTVTPDXPETLC-ZRBLBEILSA-N

View Spectrum of Ezetimibe;(3-R,4-S)-1-(4-fluoromethyl)-3[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetridin-2-one

MS (LC) Spectrum
Copyright Copyright © 2018-2025 Wiley-VCH GmbH. All Rights Reserved.
Source of Spectrum Maurer/Meyer/Helfer/Weber c/o Saarland University Homburg/Saar
Technique HCD

View Spectrum of Ezetimibe;(3-R,4-S)-1-(4-fluoromethyl)-3[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetridin-2-one

MS (LC) Spectrum
Copyright Copyright © 2012-2025 Herbert Oberacher. All Rights Reserved.
Source of Spectrum Herbert Oberacher, Institute of Legal Medicine, Innsbruck/Austria
Technique Q-TOF

View Spectrum of Ezetimibe;(3-R,4-S)-1-(4-fluoromethyl)-3[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetridin-2-one

MS (LC) Spectrum
Copyright Copyright © 2012-2025 Herbert Oberacher. All Rights Reserved.
Source of Spectrum Herbert Oberacher, Institute of Legal Medicine, Innsbruck/Austria
Technique Q-TOF

View Spectrum of Ezetimibe;(3-R,4-S)-1-(4-fluoromethyl)-3[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetridin-2-one

MS (LC) Spectrum
Copyright Copyright © 2012-2025 Herbert Oberacher. All Rights Reserved.
Source of Spectrum Herbert Oberacher, Institute of Legal Medicine, Innsbruck/Austria
Technique Q-TOF

View Spectrum of Ezetimibe;(3-R,4-S)-1-(4-fluoromethyl)-3[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetridin-2-one

MS (LC) Spectrum
Copyright Copyright © 2012-2025 Herbert Oberacher. All Rights Reserved.
Source of Spectrum Herbert Oberacher, Institute of Legal Medicine, Innsbruck/Austria
Technique Q-TOF

View Spectrum of Ezetimibe;(3-R,4-S)-1-(4-fluoromethyl)-3[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetridin-2-one

MS (LC) Spectrum
Copyright Copyright © 2012-2025 Herbert Oberacher. All Rights Reserved.
Source of Spectrum Herbert Oberacher, Institute of Legal Medicine, Innsbruck/Austria
Technique Q-TOF

View Spectrum of Ezetimibe;(3-R,4-S)-1-(4-fluoromethyl)-3[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetridin-2-one

MS (LC) Spectrum
Copyright Copyright © 2012-2025 Herbert Oberacher. All Rights Reserved.
Source of Spectrum Herbert Oberacher, Institute of Legal Medicine, Innsbruck/Austria
Technique Q-TOF

View Spectrum of Ezetimibe;(3-R,4-S)-1-(4-fluoromethyl)-3[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetridin-2-one

MS (LC) Spectrum
Copyright Copyright © 2012-2025 Herbert Oberacher. All Rights Reserved.
Source of Spectrum Herbert Oberacher, Institute of Legal Medicine, Innsbruck/Austria
Technique Q-TOF

View Spectrum of Ezetimibe;(3-R,4-S)-1-(4-fluoromethyl)-3[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetridin-2-one

MS (LC) Spectrum
Copyright Copyright © 2012-2025 Herbert Oberacher. All Rights Reserved.
Source of Spectrum Herbert Oberacher, Institute of Legal Medicine, Innsbruck/Austria
Technique Q-TOF

View Spectrum of Ezetimibe;(3-R,4-S)-1-(4-fluoromethyl)-3[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetridin-2-one

MS (LC) Spectrum
Copyright Copyright © 2012-2025 Herbert Oberacher. All Rights Reserved.
Source of Spectrum Herbert Oberacher, Institute of Legal Medicine, Innsbruck/Austria
Technique Q-TOF

View Spectrum of Ezetimibe;(3-R,4-S)-1-(4-fluoromethyl)-3[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetridin-2-one

MS (LC) Spectrum
Copyright Copyright © 2012-2025 Herbert Oberacher. All Rights Reserved.
Source of Spectrum Herbert Oberacher, Institute of Legal Medicine, Innsbruck/Austria
Technique Q-TOF

View Spectrum of Ezetimibe;(3-R,4-S)-1-(4-fluoromethyl)-3[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetridin-2-one

19F NMR Spectrum
Copyright Copyright © 2016-2025 W. Robien, Inst. of Org. Chem., Univ. of Vienna. All Rights Reserved.
Solvent HET

View Spectrum of Ezetimibe;(3-R,4-S)-1-(4-fluoromethyl)-3[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetridin-2-one

19F NMR Spectrum
Copyright Copyright © 2016-2025 W. Robien, Inst. of Org. Chem., Univ. of Vienna. All Rights Reserved.
Solvent HET

View Spectrum of Ezetimibe;(3-R,4-S)-1-(4-fluoromethyl)-3[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetridin-2-one

Vapor Phase IR Spectrum
Copyright Copyright © 2024-2025 John Wiley & Sons, Inc. All Rights Reserved.

View Spectrum of Ezetimibe;(3-R,4-S)-1-(4-fluoromethyl)-3[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetridin-2-one

13C NMR Spectrum
Copyright Copyright © 2016-2025 W. Robien, Inst. of Org. Chem., Univ. of Vienna. All Rights Reserved.
Solvent DMSO-D6

View Spectrum of Ezetimibe;(3-R,4-S)-1-(4-fluoromethyl)-3[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetridin-2-one

13C NMR Spectrum
Copyright Copyright © 2016-2025 W. Robien, Inst. of Org. Chem., Univ. of Vienna. All Rights Reserved.
Solvent CDCl3+DROPS_OF-DMSO-D6

View Spectrum of Ezetimibe;(3-R,4-S)-1-(4-fluoromethyl)-3[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetridin-2-one

13C NMR Spectrum
Copyright Copyright © 2016-2025 W. Robien, Inst. of Org. Chem., Univ. of Vienna. All Rights Reserved.
Solvent DMSO-D6
  • EZETIMIBE;1-(4-FLUOROPHENYL)-3-(R)-[3-(4-FLUOROPHENYL)-3-(S)-HYDROXYPROPYL]-4-(S)-(4-HYDROXYPHENYL)-2-AZETIDINONE
  • Ezetimib
  • Ezetimibe
  • (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
EZETIMIBE;EZE;1-(4-FLUOROPHENYL)-3-(R)-[3-(4-FLUOROPHENYL)-3-(S)-HYDROXYPROPYL]-4-(S)-(4-HYDROXYPHENYL)-2-AZETIDINONE
Ethyl 4-(4-methoxyphenyl)-2-oxo-1-phenyl-1-azacyclobutane-3-carboxylate
Ethyl 1-(4-methoxyphenyl)-2-oxo-4-phenyl-1-azacyclobutane-3-carboxylate
1-(p-Dimethylaminophenyl)-3,4-diphenyl-2-azetidinone
3,4-trans-N-(Carbobenzyloxy)-3-amino-4-phenylazetidin-2-one
1,4-Diphenyl-3-(p-methoxyphenyl)-2-azetidinone
3-(p-Chlorophenyl)-1,4-diphenyl-2-azetidinone
3,3-Pentamethylene-1,4-diphenylazetidin-2-one
3-Chloro-4-(3-nitrophenyl)-1-(4-(phenyldiazenyl)phenyl)azetidin-2-one
4-Keto-1,2-diphenyl-nipecotic acid ethyl ester
Title Journal or Book Year
Structure of the major degradant of ezetimibe Journal of Pharmaceutical and Biomedical Analysis 2012
Structural elucidation of a process-related impurity in ezetimibe by LC/MS/MS and NMR Journal of Pharmaceutical and Biomedical Analysis 2010
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