Spectra for:
Nicholas A. Magnus, Pat N. Confalone, Louis Storace, Mona Patel, Christopher C. Wood, Wayne P. Davis, Rodney L. Parsons
Compound 1 (4S)-6-CHLORO-4-(2-CYCLOPROPYLETHYNYL)-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE
Compound 5 6-CHLORO-4-HYDROXY-1-[(4-METHOXYPHENYL)-METHYL]-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE
![6-CHLORO-4-HYDROXY-1-[(4-METHOXYPHENYL)-METHYL]-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE](/api/compound/5zuFBeRSU54.png?h=300&w=458 "6-CHLORO-4-HYDROXY-1-[(4-METHOXYPHENYL)-METHYL]-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE")
Compound 6 6-CHLORO-1-[(4-METHOXYPHENYL)-METHYL]-4-(TRIFLUOROMETHYL)-HYDROQUINAZOLIN-2-ONE
![6-CHLORO-1-[(4-METHOXYPHENYL)-METHYL]-4-(TRIFLUOROMETHYL)-HYDROQUINAZOLIN-2-ONE](/api/compound/8cT9vC48deQ.png?h=300&w=458 "6-CHLORO-1-[(4-METHOXYPHENYL)-METHYL]-4-(TRIFLUOROMETHYL)-HYDROQUINAZOLIN-2-ONE")
Compound 7 6-CHLORO-4-(2-CYCLOPROPYLETHYNYL)-1-[(4-METHOXYPHENYL)-METHYL]-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE
![6-CHLORO-4-(2-CYCLOPROPYLETHYNYL)-1-[(4-METHOXYPHENYL)-METHYL]-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE](/api/compound/IJRsxpEid7b.png?h=300&w=458 "6-CHLORO-4-(2-CYCLOPROPYLETHYNYL)-1-[(4-METHOXYPHENYL)-METHYL]-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE")
Compound 10-MAJOR-DIASTEREOMER 3-[(1R)-1-PHENYLETHYL]-(4S)-6-CHLORO-4-HYDROXY-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE
![3-[(1R)-1-PHENYLETHYL]-(4S)-6-CHLORO-4-HYDROXY-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE](/api/compound/Fqx60lLFBnT.png?h=300&w=458 "3-[(1R)-1-PHENYLETHYL]-(4S)-6-CHLORO-4-HYDROXY-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE")
Compound 11 3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-(TRIFLUOROMETHYL)-3-HYDROQUINAZOLIN-2-ONE
![3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-(TRIFLUOROMETHYL)-3-HYDROQUINAZOLIN-2-ONE](/api/compound/CtNvsOJEiPb.png?h=300&w=458 "3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-(TRIFLUOROMETHYL)-3-HYDROQUINAZOLIN-2-ONE")
Compound 12-MAJOR-DIASTEREOMER 3-[(1R)-1-PHENYLETHYL]-(4S)-6-CHLORO-4-(2-CYCLOPROPYLETHYNYL)-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE
![3-[(1R)-1-PHENYLETHYL]-(4S)-6-CHLORO-4-(2-CYCLOPROPYLETHYNYL)-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE](/api/compound/5IfzsploKPo.png?h=300&w=458 "3-[(1R)-1-PHENYLETHYL]-(4S)-6-CHLORO-4-(2-CYCLOPROPYLETHYNYL)-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE")
Compound 13- MAJOR-DIASTEREOMER 3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-METHOXY-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE
![3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-METHOXY-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE](/api/compound/8M8NNg2WCze.png?h=300&w=458 "3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-METHOXY-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE")
Compound 14-MA JOR-DIASTEREOMER 3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-(TRIFLUOROMETHYL)-4-VINYL-1,3,4-TRIHYDROQUINAZOLIN-2-ONE
![3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-(TRIFLUOROMETHYL)-4-VINYL-1,3,4-TRIHYDROQUINAZOLIN-2-ONE](/api/compound/3WE7zC5EZHe.png?h=300&w=458 "3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-(TRIFLUOROMETHYL)-4-VINYL-1,3,4-TRIHYDROQUINAZOLIN-2-ONE")
Compound 15-M AJOR-DIASTEREOMER 3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-PHENYL-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE
![3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-PHENYL-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE](/api/compound/6VTBsHIooVv.png?h=300&w=458 "3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-PHENYL-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE")
Compound 16-M ORE-POLAR-DIASTEREOMER 3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-BENZYL-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE
![3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-BENZYL-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE](/api/compound/2uxck1eupPp.png?h=300&w=458 "3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-BENZYL-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE")
Compound 17-M AJOR-DIASTEREOMER 3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-METHYL-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE
![3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-METHYL-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE](/api/compound/9KAWEKlWQ34.png?h=300&w=458 "3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-METHYL-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE")
Compound 18 3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE;MAJOR-DIASTEREOMER
![3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE;MAJOR-DIASTEREOMER](/api/compound/L1ifuePd7Es.png?h=300&w=458 "3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE;MAJOR-DIASTEREOMER")
Compound 18-MINOR-DIAS TEREOMER 3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE
![3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE](/api/compound/BwpvOWN80eG.png?h=300&w=458 "3-[(1R)-1-PHENYLETHYL]-6-CHLORO-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-2-ONE")
Compound 19-MAJOR-DIASTEREOMER (4S)-6-chloro-4-[(E)-2-cyclopropyl-2-pyrrolidin-1-ylethenyl]-3-[(1R)-1-phenylethyl]-4-(trifluoromethyl)-1H-quinazolin-2-one
![(4S)-6-chloro-4-[(E)-2-cyclopropyl-2-pyrrolidin-1-ylethenyl]-3-[(1R)-1-phenylethyl]-4-(trifluoromethyl)-1H-quinazolin-2-one](/api/compound/FvDuLslmzs6.png?h=300&w=458 "(4S)-6-chloro-4-[(E)-2-cyclopropyl-2-pyrrolidin-1-ylethenyl]-3-[(1R)-1-phenylethyl]-4-(trifluoromethyl)-1H-quinazolin-2-one")
#8A;1-[[(4S)-6-CHLORO-4-(2-CYCLOPROPYLETHYNYL)-1-[(4-METHOXYPHENYL)-METHYL]-2-OXO-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-3-YL]-CARBONYL]-4,7,7-TRIMETHYL-
![#8A;1-[[(4S)-6-CHLORO-4-(2-CYCLOPROPYLETHYNYL)-1-[(4-METHOXYPHENYL)-METHYL]-2-OXO-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-3-YL]-CARBONYL]-4,7,7-TRIMETHYL-](/api/compound/CUkLFWCVGAW.png?h=300&w=458 "#8A;1-[[(4S)-6-CHLORO-4-(2-CYCLOPROPYLETHYNYL)-1-[(4-METHOXYPHENYL)-METHYL]-2-OXO-4-(TRIFLUOROMETHYL)-1,3,4-TRIHYDROQUINAZOLIN-3-YL]-CARBONYL]-4,7,7-TRIMETHYL-")
N-[2-[(3R)-(1Z)-2-AZA-3-PHENYL-1-(TRIFLUOROMETHYL)-BUT-1-ENYL]-4-CHLOROPHENYL]-3-CYCLOPROPYLPROP-2-YNAMIDE
![N-[2-[(3R)-(1Z)-2-AZA-3-PHENYL-1-(TRIFLUOROMETHYL)-BUT-1-ENYL]-4-CHLOROPHENYL]-3-CYCLOPROPYLPROP-2-YNAMIDE](/api/compound/1xDZBvC1CVx.png?h=300&w=458 "N-[2-[(3R)-(1Z)-2-AZA-3-PHENYL-1-(TRIFLUOROMETHYL)-BUT-1-ENYL]-4-CHLOROPHENYL]-3-CYCLOPROPYLPROP-2-YNAMIDE")
N-[2-[(3R)-(1Z)-2-AZA-3-PHENYL-1-(TRIFLUOROMETHYL)-BUT-1-ENYL]-4-CHLOROPHENYL]-3-CYCLOPROPYLPROP-2-YNAMIDE
![N-[2-[(3R)-(1Z)-2-AZA-3-PHENYL-1-(TRIFLUOROMETHYL)-BUT-1-ENYL]-4-CHLOROPHENYL]-3-CYCLOPROPYLPROP-2-YNAMIDE](/api/compound/4tMXaX2VHAK.png?h=300&w=458 "N-[2-[(3R)-(1Z)-2-AZA-3-PHENYL-1-(TRIFLUOROMETHYL)-BUT-1-ENYL]-4-CHLOROPHENYL]-3-CYCLOPROPYLPROP-2-YNAMIDE")
N-[2-[(3R)-(1Z)-2-AZA-3-PHENYL-1-(TRIFLUOROMETHYL)-BUT-1-ENYL]-4-CHLOROPHENYL]-METHOXYCARBOXAMIDE
![N-[2-[(3R)-(1Z)-2-AZA-3-PHENYL-1-(TRIFLUOROMETHYL)-BUT-1-ENYL]-4-CHLOROPHENYL]-METHOXYCARBOXAMIDE](/api/compound/K1OS53hHWOd.png?h=300&w=458 "N-[2-[(3R)-(1Z)-2-AZA-3-PHENYL-1-(TRIFLUOROMETHYL)-BUT-1-ENYL]-4-CHLOROPHENYL]-METHOXYCARBOXAMIDE")
Citation
| Citation | J.ORG.CHEM.,68,754(2003) |
|---|---|
| Journal | The Journal of Organic Chemistry |
| Issue | 3 |
| Volume | 68 |
| Page(s) | 754-761 |
| Year | 2002 |
| Author(s) | Nicholas A. Magnus, Pat N. Confalone, Louis Storace, Mona Patel, Christopher C. Wood, Wayne P. Davis, Rodney L. Parsons |
| Publisher | American Chemical Society (ACS) |
| DOI | 10.1021/jo0263162 |