Spectra for:
Dimitri Topalis, Ugo Pradère, Vincent Roy, Christophe Caillat, Ahmed Azzouzi, Julie Broggi, Robert Snoeck, Graciela Andrei, Jay Lin, Staffan Eriksson, Julie A. C. Alexandre, Chahrazade El-Amri, Dominique Deville-Bonne, Philippe Meyer, Jan Balzarini, Luigi A. Agrofoglio
Compound 5B N-(1)-[(E)-3-DIETHOXYPHOSPHONYLPROP-2-ENYL]-5-FLUOROURACIL
![N-(1)-[(E)-3-DIETHOXYPHOSPHONYLPROP-2-ENYL]-5-FLUOROURACIL](/api/compound/mrdjvbxRzl.png?h=300&w=458 "N-(1)-[(E)-3-DIETHOXYPHOSPHONYLPROP-2-ENYL]-5-FLUOROURACIL")
Compound 5E N-(1)-[(E)-3-diethoxyphosphonylprop-2-enyl]-thymine
![N-(1)-[(E)-3-diethoxyphosphonylprop-2-enyl]-thymine](/api/compound/8At7YfZm9Z3.png?h=300&w=458 "N-(1)-[(E)-3-diethoxyphosphonylprop-2-enyl]-thymine")
Compound 6B N-(1)-[(E)-DIHYDROXYPHOSPHONYLPROP-2-ENYL]-5-FLUOROURACIL
![N-(1)-[(E)-DIHYDROXYPHOSPHONYLPROP-2-ENYL]-5-FLUOROURACIL](/api/compound/HKUu1PsvcCm.png?h=300&w=458 "N-(1)-[(E)-DIHYDROXYPHOSPHONYLPROP-2-ENYL]-5-FLUOROURACIL")
Compound 6E N-(1)-[(E)-3--DIHYDROXYPHOSPHONYLPROP-2-ENYL]-THYMINE
![N-(1)-[(E)-3--DIHYDROXYPHOSPHONYLPROP-2-ENYL]-THYMINE](/api/compound/JL9iz48tVZn.png?h=300&w=458 "N-(1)-[(E)-3--DIHYDROXYPHOSPHONYLPROP-2-ENYL]-THYMINE")
Compound 7B N-(3)-Benzoyl-N-(1)-[(E)-4-dimethoxyphosphonylbut-2-enyl]-5-fluorouracil
![N-(3)-Benzoyl-N-(1)-[(E)-4-dimethoxyphosphonylbut-2-enyl]-5-fluorouracil](/api/compound/DoUMeWmb7jj.png?h=300&w=458 "N-(3)-Benzoyl-N-(1)-[(E)-4-dimethoxyphosphonylbut-2-enyl]-5-fluorouracil")
Compound 7E N-(3)-Benzoyl-N-(1)-[(E)-4-dimethoxyphosphonylbut-2-enyl]-thymine
![N-(3)-Benzoyl-N-(1)-[(E)-4-dimethoxyphosphonylbut-2-enyl]-thymine](/api/compound/394ze07n4yF.png?h=300&w=458 "N-(3)-Benzoyl-N-(1)-[(E)-4-dimethoxyphosphonylbut-2-enyl]-thymine")
Compound 8A N-(1)-[(E)-4-DIMETHOXYPHOSPHONYLBUT-2-ENYL]-URACIL
![N-(1)-[(E)-4-DIMETHOXYPHOSPHONYLBUT-2-ENYL]-URACIL](/api/compound/7rk0vB1lYpl.png?h=300&w=458 "N-(1)-[(E)-4-DIMETHOXYPHOSPHONYLBUT-2-ENYL]-URACIL")
Compound 8B N-(1)-[(ZX)-4-DIMETHOXYPHOSPHONYLBUT-2-ENYL]-5-FLUOROURACIL
![N-(1)-[(ZX)-4-DIMETHOXYPHOSPHONYLBUT-2-ENYL]-5-FLUOROURACIL](/api/compound/L38Uts2e5yg.png?h=300&w=458 "N-(1)-[(ZX)-4-DIMETHOXYPHOSPHONYLBUT-2-ENYL]-5-FLUOROURACIL")
Compound 8C N-(1)-[(EX)-4-DIMETHOXYPHOSPHONYLBUT-2-ENYL]-5-CHLOROURACIL
![N-(1)-[(EX)-4-DIMETHOXYPHOSPHONYLBUT-2-ENYL]-5-CHLOROURACIL](/api/compound/Ic0Vz93XvUn.png?h=300&w=458 "N-(1)-[(EX)-4-DIMETHOXYPHOSPHONYLBUT-2-ENYL]-5-CHLOROURACIL")
Compound 8D N-(1)-[(Z)-4-DIMETHOXYPHOSPHONYLBUT-2-ENYL]-5-BROMOURACIL
![N-(1)-[(Z)-4-DIMETHOXYPHOSPHONYLBUT-2-ENYL]-5-BROMOURACIL](/api/compound/CG6YoY2Mpte.png?h=300&w=458 "N-(1)-[(Z)-4-DIMETHOXYPHOSPHONYLBUT-2-ENYL]-5-BROMOURACIL")
Compound 8E N-(1)-[(E)-4-DIMETHOXYPHOSPHONYLBUT-2-ENYL]-THYMINE
![N-(1)-[(E)-4-DIMETHOXYPHOSPHONYLBUT-2-ENYL]-THYMINE](/api/compound/7r6ehUThXm8.png?h=300&w=458 "N-(1)-[(E)-4-DIMETHOXYPHOSPHONYLBUT-2-ENYL]-THYMINE")
Compound 9B N-(1)-[(Z)4-DIHYDROXYPHOSPHONYLBUT-2-ENYL]-5-FLUOROURACIL
![N-(1)-[(Z)4-DIHYDROXYPHOSPHONYLBUT-2-ENYL]-5-FLUOROURACIL](/api/compound/IGxODAgqY4w.png?h=300&w=458 "N-(1)-[(Z)4-DIHYDROXYPHOSPHONYLBUT-2-ENYL]-5-FLUOROURACIL")
Compound 9E N-(1)-[(E)-4-DIHYDROXYPHOSPHONYLBUT-2-ENYL]-THYMINE
![N-(1)-[(E)-4-DIHYDROXYPHOSPHONYLBUT-2-ENYL]-THYMINE](/api/compound/Dft7klxjRaz.png?h=300&w=458 "N-(1)-[(E)-4-DIHYDROXYPHOSPHONYLBUT-2-ENYL]-THYMINE")
Compound 12D N-(1)-[(Z)-4-DIHYDROXYPHOSPHONYLBUT-2-ENYL]-5-BROMOURACIL
![N-(1)-[(Z)-4-DIHYDROXYPHOSPHONYLBUT-2-ENYL]-5-BROMOURACIL](/api/compound/3kbKHbNB0nF.png?h=300&w=458 "N-(1)-[(Z)-4-DIHYDROXYPHOSPHONYLBUT-2-ENYL]-5-BROMOURACIL")
Compound 13A N-(3)-Benzoyl-N-(1)-[(E)-5-diethoxyphosphonylpent-2-enyl]-uracil
![N-(3)-Benzoyl-N-(1)-[(E)-5-diethoxyphosphonylpent-2-enyl]-uracil](/api/compound/uXltTdgbLv.png?h=300&w=458 "N-(3)-Benzoyl-N-(1)-[(E)-5-diethoxyphosphonylpent-2-enyl]-uracil")
Compound 13B N-(3)-Benzoyl-N-(1)-[(E)-5-diethoxyphosphonylpent-2-enyl]-5-fluorouracil
![N-(3)-Benzoyl-N-(1)-[(E)-5-diethoxyphosphonylpent-2-enyl]-5-fluorouracil](/api/compound/6BRm4ELWBjg.png?h=300&w=458 "N-(3)-Benzoyl-N-(1)-[(E)-5-diethoxyphosphonylpent-2-enyl]-5-fluorouracil")
Compound 13C N-(3)-BENZOYL-N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-5-CHLOROURACIL
![N-(3)-BENZOYL-N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-5-CHLOROURACIL](/api/compound/3RYCjEhYlnh.png?h=300&w=458 "N-(3)-BENZOYL-N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-5-CHLOROURACIL")
Compound 13D N-(3)-BENZOYL-N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-5-BROMOURACIL
![N-(3)-BENZOYL-N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-5-BROMOURACIL](/api/compound/JNBf0zymEtk.png?h=300&w=458 "N-(3)-BENZOYL-N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-5-BROMOURACIL")
Compound 13E N-(3)-Benzoyl-N-(1)-[(E)-5-diethoxyphosphonylpent-2-enyl]-thymine
![N-(3)-Benzoyl-N-(1)-[(E)-5-diethoxyphosphonylpent-2-enyl]-thymine](/api/compound/5FMFlnbDeuU.png?h=300&w=458 "N-(3)-Benzoyl-N-(1)-[(E)-5-diethoxyphosphonylpent-2-enyl]-thymine")
Compound 14A N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-URACIL
![N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-URACIL](/api/compound/CEVjigoXr2X.png?h=300&w=458 "N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-URACIL")
Compound 14B N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-5-FLUOROURACIL
![N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-5-FLUOROURACIL](/api/compound/GPEFQnrxEmn.png?h=300&w=458 "N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-5-FLUOROURACIL")
Compound 14C N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-5-CHLOROURACIL
![N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-5-CHLOROURACIL](/api/compound/KA2L4CAc5sM.png?h=300&w=458 "N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-5-CHLOROURACIL")
Compound 14D N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-5-BROMOURACIL
![N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-5-BROMOURACIL](/api/compound/BxfbHGVl3FF.png?h=300&w=458 "N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-5-BROMOURACIL")
Compound 14E N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-THYMINE
![N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-THYMINE](/api/compound/5DCC8sHdOH8.png?h=300&w=458 "N-(1)-[(E)-5-DIETHOXYPHOSPHONYLPENT-2-ENYL]-THYMINE")
Compound 15A N-(1)-[(E)-5-DIHYDROXYPHOSPHONYLPENT-2-ENYL]-URACIL
![N-(1)-[(E)-5-DIHYDROXYPHOSPHONYLPENT-2-ENYL]-URACIL](/api/compound/BCfEynrF2Nk.png?h=300&w=458 "N-(1)-[(E)-5-DIHYDROXYPHOSPHONYLPENT-2-ENYL]-URACIL")
Compound 15B N-(1)-[(E)-5-DIHYDROXYPHOSPHONYLPENT-2-ENYL]-5-FLUOROURACIL
![N-(1)-[(E)-5-DIHYDROXYPHOSPHONYLPENT-2-ENYL]-5-FLUOROURACIL](/api/compound/H5jtTXWanxR.png?h=300&w=458 "N-(1)-[(E)-5-DIHYDROXYPHOSPHONYLPENT-2-ENYL]-5-FLUOROURACIL")
Compound 15C N-(1)-[(E)-5-DIHYDROXYPHOSPHONYLPENT-2-ENYL]-5-CHLOROURACIL
![N-(1)-[(E)-5-DIHYDROXYPHOSPHONYLPENT-2-ENYL]-5-CHLOROURACIL](/api/compound/I5be7os28hw.png?h=300&w=458 "N-(1)-[(E)-5-DIHYDROXYPHOSPHONYLPENT-2-ENYL]-5-CHLOROURACIL")
Compound 15D N-(1)-[(E)5--DIHYDROXYPHOSPHONYLPENT-2-ENYL]-5-BROMOURACIL
![N-(1)-[(E)5--DIHYDROXYPHOSPHONYLPENT-2-ENYL]-5-BROMOURACIL](/api/compound/LdrMqweYURF.png?h=300&w=458 "N-(1)-[(E)5--DIHYDROXYPHOSPHONYLPENT-2-ENYL]-5-BROMOURACIL")
Compound 15E N-(1)-[(E)-5-DIHYDROXYPHOSPHONYL-2-ENYL]-THYMINE
![N-(1)-[(E)-5-DIHYDROXYPHOSPHONYL-2-ENYL]-THYMINE](/api/compound/JbFdmjaUNdL.png?h=300&w=458 "N-(1)-[(E)-5-DIHYDROXYPHOSPHONYL-2-ENYL]-THYMINE")
Compound 16 N-(1)-[(E)-4-bis-(pivaloyloxymethyl)-phosphinylbuten-2-yl]-thymine
![N-(1)-[(E)-4-bis-(pivaloyloxymethyl)-phosphinylbuten-2-yl]-thymine](/api/compound/LYPnjuTHi2h.png?h=300&w=458 "N-(1)-[(E)-4-bis-(pivaloyloxymethyl)-phosphinylbuten-2-yl]-thymine")
Compound 18 N-(1)-[(E)-4-bis-(pivaloyloxymethyl)-phosphinyl-2-butenyl]-5-bromouracil
![N-(1)-[(E)-4-bis-(pivaloyloxymethyl)-phosphinyl-2-butenyl]-5-bromouracil](/api/compound/HtMaQiI5kJL.png?h=300&w=458 "N-(1)-[(E)-4-bis-(pivaloyloxymethyl)-phosphinyl-2-butenyl]-5-bromouracil")
Citation
| Citation | J.MED.CHEM.,54,222(2011) |
|---|---|
| Journal | Journal of Medicinal Chemistry |
| Issue | 1 |
| Volume | 54 |
| Page(s) | 222-232 |
| Year | 2010 |
| Author(s) | Dimitri Topalis, Ugo Pradère, Vincent Roy, Christophe Caillat, Ahmed Azzouzi, Julie Broggi, Robert Snoeck, Graciela Andrei, Jay Lin, Staffan Eriksson, Julie A. C. Alexandre, Chahrazade El-Amri, Dominique Deville-Bonne, Philippe Meyer, Jan Balzarini, Luigi A. Agrofoglio |
| Publisher | American Chemical Society (ACS) |
| DOI | 10.1021/jm1011462 |