Spectra for:
Stella Soukara, Christoph A. Maier, Ursula Predoiu, Andreas Ehret, Rolf Jackisch, Bernhard Wünsch
Compound (R)-18 (+)-1-[(2-R)-1-BENZYL-4-BUTYL-PIPERAZIN-2-YL]-ETHAN-1-ONE
![(+)-1-[(2-R)-1-BENZYL-4-BUTYL-PIPERAZIN-2-YL]-ETHAN-1-ONE](/api/compound/3fUSCQLtZpn.png?h=300&w=458 "(+)-1-[(2-R)-1-BENZYL-4-BUTYL-PIPERAZIN-2-YL]-ETHAN-1-ONE")
Compound (R)-19 (+)-1-[(2-R)-1-BENZYL-4-PHENYL-PIPERAZIN-2-YL]-ETHAN-1-ONE
![(+)-1-[(2-R)-1-BENZYL-4-PHENYL-PIPERAZIN-2-YL]-ETHAN-1-ONE](/api/compound/DKOglRi7qdg.png?h=300&w=458 "(+)-1-[(2-R)-1-BENZYL-4-PHENYL-PIPERAZIN-2-YL]-ETHAN-1-ONE")
Compound (R)-9 (+)-TERT.-BUTYL-(R)-3-ACETYL-4-BENZYL-PIPERAZINE-1-CARBOXYLATE
Compound (R,R)-10 (+)-TERT.-BUTYL-(R)-4-BENZYL-3-[(R)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE-1-CARBOXYLATE
![(+)-TERT.-BUTYL-(R)-4-BENZYL-3-[(R)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE-1-CARBOXYLATE](/api/compound/GTtMtWgpeUR.png?h=300&w=458 "(+)-TERT.-BUTYL-(R)-4-BENZYL-3-[(R)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE-1-CARBOXYLATE")
Compound (R,R)-11 (-)-TERT.-BUTYL-(R)-4-[2-(3,4-DICHLOROPHENYL)-ACETYL]-3-[(R)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE-1-CARBOXYLATE;MAJOR-ROTAMER
![(-)-TERT.-BUTYL-(R)-4-[2-(3,4-DICHLOROPHENYL)-ACETYL]-3-[(R)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE-1-CARBOXYLATE;MAJOR-ROTAMER](/api/compound/BsnlGXrkump.png?h=300&w=458 "(-)-TERT.-BUTYL-(R)-4-[2-(3,4-DICHLOROPHENYL)-ACETYL]-3-[(R)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE-1-CARBOXYLATE;MAJOR-ROTAMER")
Compound (R,R)-13 (-)-1-[(R)-4-[2-(3,4-DICHLOROPHENYL)-ACETYL]-3-[(R)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZIN-1-YL]-PROPAN-1-ONE;MAJOR-ROTAMER
![(-)-1-[(R)-4-[2-(3,4-DICHLOROPHENYL)-ACETYL]-3-[(R)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZIN-1-YL]-PROPAN-1-ONE;MAJOR-ROTAMER](/api/compound/ENj5EspJ8FW.png?h=300&w=458 "(-)-1-[(R)-4-[2-(3,4-DICHLOROPHENYL)-ACETYL]-3-[(R)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZIN-1-YL]-PROPAN-1-ONE;MAJOR-ROTAMER")
Compound (R,R)-14 (-)-METHYL-(R)-4-[2-(3,4-DICHLOROPHENYL)-ACETYL]-3-[(R)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE-1-CARBOXYLATE;MAJOR-ROTAMER
![(-)-METHYL-(R)-4-[2-(3,4-DICHLOROPHENYL)-ACETYL]-3-[(R)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE-1-CARBOXYLATE;MAJOR-ROTAMER](/api/compound/7CZhBENtyKQ.png?h=300&w=458 "(-)-METHYL-(R)-4-[2-(3,4-DICHLOROPHENYL)-ACETYL]-3-[(R)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE-1-CARBOXYLATE;MAJOR-ROTAMER")
Compound (R,R)-20 (R)-(+)-1-BENZYL-4-BUTYL-2-[(R)-1-PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE
![(R)-(+)-1-BENZYL-4-BUTYL-2-[(R)-1-PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE](/api/compound/9TM1N3zlI22.png?h=300&w=458 "(R)-(+)-1-BENZYL-4-BUTYL-2-[(R)-1-PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE")
Compound (R,S)-10 (+)-TERT.-BUTYL-(R)-4-BENZYL-3-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE-1-CARBOXYLATE
![(+)-TERT.-BUTYL-(R)-4-BENZYL-3-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE-1-CARBOXYLATE](/api/compound/K5fbPdorSVP.png?h=300&w=458 "(+)-TERT.-BUTYL-(R)-4-BENZYL-3-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE-1-CARBOXYLATE")
Compound (R,S)-11 (+)-TERT.-BUTYL-(R)-4-[2-(3,4-DICHLOROPHENYL)-ACETYL]-3-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE-1-CARBOXYLATE;MAJOR-ROTAMER
![(+)-TERT.-BUTYL-(R)-4-[2-(3,4-DICHLOROPHENYL)-ACETYL]-3-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE-1-CARBOXYLATE;MAJOR-ROTAMER](/api/compound/GwvqbjeABKd.png?h=300&w=458 "(+)-TERT.-BUTYL-(R)-4-[2-(3,4-DICHLOROPHENYL)-ACETYL]-3-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE-1-CARBOXYLATE;MAJOR-ROTAMER")
Compound (R,S)-13 (+)-1-[(R)-4-[2-(3,4-DICHLOROPHENYL)-ACETYL]-3-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZIN-1-YL]-PROPAN-1-ONE;MAJOR-ROTAMER
![(+)-1-[(R)-4-[2-(3,4-DICHLOROPHENYL)-ACETYL]-3-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZIN-1-YL]-PROPAN-1-ONE;MAJOR-ROTAMER](/api/compound/KGZ9KK1TD3a.png?h=300&w=458 "(+)-1-[(R)-4-[2-(3,4-DICHLOROPHENYL)-ACETYL]-3-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZIN-1-YL]-PROPAN-1-ONE;MAJOR-ROTAMER")
Compound (R,S)-14 (+)-METHYL-(R)-4-[2-(3,4-DICHLOROPHENYL)-ACETYL]-3-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE-1-CARBOXYLATE;MAJOR-ROTAMER
![(+)-METHYL-(R)-4-[2-(3,4-DICHLOROPHENYL)-ACETYL]-3-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE-1-CARBOXYLATE;MAJOR-ROTAMER](/api/compound/KXzlMdItB0.png?h=300&w=458 "(+)-METHYL-(R)-4-[2-(3,4-DICHLOROPHENYL)-ACETYL]-3-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE-1-CARBOXYLATE;MAJOR-ROTAMER")
Compound (R,S)-20 (R)-(+)-1-BENZYL-4-BUTYL-2-[(S)-1-PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE
![(R)-(+)-1-BENZYL-4-BUTYL-2-[(S)-1-PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE](/api/compound/ABVHdLGhEHj.png?h=300&w=458 "(R)-(+)-1-BENZYL-4-BUTYL-2-[(S)-1-PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE")
Compound (R,S)-21 (R)-(+)-1-BENZYL-4-PHENYL-2-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE
![(R)-(+)-1-BENZYL-4-PHENYL-2-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE](/api/compound/CfAlfU0H7n4.png?h=300&w=458 "(R)-(+)-1-BENZYL-4-PHENYL-2-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZINE")
Compound (R,S)-22 (+)-1-[(R)-4-BUTYL-2-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZIN-1-YL]-2-(3,4-DICHLOROPHENYL)-ETHAN-1-ONE;MAJOR-ROTAMER
![(+)-1-[(R)-4-BUTYL-2-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZIN-1-YL]-2-(3,4-DICHLOROPHENYL)-ETHAN-1-ONE;MAJOR-ROTAMER](/api/compound/Gd5PTecSlpA.png?h=300&w=458 "(+)-1-[(R)-4-BUTYL-2-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZIN-1-YL]-2-(3,4-DICHLOROPHENYL)-ETHAN-1-ONE;MAJOR-ROTAMER")
Compound (R,S)-23 (+)-2-(3,4-DICHLOROPHENYL)-1-[(R)-4-PHENYL-2-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZIN-1-YL]-ETHAN-1-ONE;MAJOR-ROTAMER
![(+)-2-(3,4-DICHLOROPHENYL)-1-[(R)-4-PHENYL-2-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZIN-1-YL]-ETHAN-1-ONE;MAJOR-ROTAMER](/api/compound/11pLmePq2WJ.png?h=300&w=458 "(+)-2-(3,4-DICHLOROPHENYL)-1-[(R)-4-PHENYL-2-[(S)-1-(PYRROLIDIN-1-YL)-ETHYL]-PIPERAZIN-1-YL]-ETHAN-1-ONE;MAJOR-ROTAMER")
Citation
| Citation | J.MED.CHEM.,44,2814(2001) |
|---|---|
| Journal | Journal of Medicinal Chemistry |
| Issue | 17 |
| Volume | 44 |
| Page(s) | 2814-2826 |
| Year | 2001 |
| Author(s) | Stella Soukara, Christoph A. Maier, Ursula Predoiu, Andreas Ehret, Rolf Jackisch, Bernhard Wünsch |
| Publisher | American Chemical Society (ACS) |
| DOI | 10.1021/jm0108395 |